To know how to make a fashion, not ride on

The Toll like receptor is popular now in the field of immunology. Once, all papers of virology were filled with the Toll like receptor. Of course the wave of science is important. Riding on the fashion is a good way to get many outcomes. However, to make a fashion is more interesting. In other words, to make a novel area of science is the most valuable result of scholars. Therefore, we should know how to make a fashion, not how to ride on it.