HIV-1 research contributes to wide biology

To study human immunodeficiency virus-1 has contributed to the development of many fields of biology. For example, the cell-nucleus traffic of HIV-1 molecules is sometimes used as a cellular model of that. The mechanism of HIV-1 budding is considered to resemble to the cell separation during cytokinesis. The population of HIV-1 researchers is significantly larger than that of scientists regarding other viruses. Nevertheless, there are many unsolved questions in the field of HIV-1 virology. It is still unknown how HIV-1 core is broken when it enters a host cell. We wonder how RNA genomes and viral proteins gather and form viral particles during viral assembly. When a problem about HIV-1 is solved, we obtain a novel finding that concerns not only virology, but also whole biology.