Vesicular stomatitis virus generates mutated genome per one replication

 Vesicular stomatitis virus (VSV) is a nonsegment negative strand (NNS) RNA virus that is broadly available for the molecular biological study of RNA polymerase because it shows the highest efficiency of polymerase activity among all known NNS RNA viruses. The most striking feature of RNA polymerase of NNS virus is the high frequency of error rate that results in production of highly mutated viral genome RNA. In case of VSV, it incorporates incorrect nucleotide at the rate of 1/1000-1/10000. Therefore, VSV polymerase generates an average of one mutation per genome and copying event.