Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19

The multi-omic profiling of peripheral bloods from 64 COVID-19 patients with mild to fatal cases revealed a hyperactivation of neutrophil and NK cells was remarkable in severe and fatal cases. The pattern of chromatin accessibility at NF-kB binding sites within cytokine gene loci in monocyte was different between mild and severe/fatal cases. Increased chromatin accessibility was observed in mild case, whereas decreased accessibility was obvious in severe case, which is correlated with the lack of pro-inflammatory cytokine production in monocyte in severe/fatal cases. The emergence of myelopoiesis was also found as a prominent feature of a fatal COVID-19 case.