Multi-omics insight into host-viral response and pathogenesis in Crimean-Congo hemorrhagic fever viruses for novel therapeutic target

A multi-omics approach for human PBMC from patients in the acute phase of Crimean-Congo hemorrhagic fever virus (CCHFV) infection was performed to compare with the convalescent phase. Moreover, a proteomic analysis was performed in CCHFV-infected culture cells such as Huh7 and SW13 cells, which are permissive for CCHFV infection in vitro. It was found that the central carbon and energy metabolism was reprogrammed, and blocking the key pathways such as glycolysis and glutaminolysis was resulted in the reduction of CCHFV replication in the culture cells.