The endonuclease activity of segmented negative-sense RNA viral polymerase is essential for cap-snatching that is a critical step for viral transcription of mRNA. Using a cap-dependent endonuclease inhibitor screening, the compound that effectively inhibits the growth of Lassa virus, lymphocytic choriomeningitis virus and Junin virus was identified. This was 100 to 1000 times more active than ribavirin that has been known as a polymerase inhibitor. This new compound is a potent broad-spectrum antiviral as the cap-snatching inhibitor for segmented negative sense RNA viruses.
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