Maternal immunization using a protein subunit vaccine mediates passive immunity against Zaire ebolavirus in a murine model

Clinical trials of Ebola vaccine did not include pregnant or nursing women, resulting in a gap in knowledge of vaccine-elicited maternal antibody. In this study, using pregnant mice model, authors revealed that the Ebola protein subunit vaccine can elicit robust humoral immune responses, and they can be transferred to pups and breastmilk. The intramuscular protein subunit vaccine may elicit Ebola-specific IgG capable of being transferred across the placenta as well as into the breastmilk.