A SARS-CoV-2 infection model in mice demonstrates protection by neutralizing antibodies

Commercially available mice were not used for a in vivo SARS-CoV-2 infection model, because mouse ACE2 is not available as the viral receptor. In this report, it was shown that BALB/c mice , a laboratory mouse strain, transduction with adenoviruses encoding human ACE2 are permissive for SARS-CoV-2. Intranasal inoculation of the adenovirus vector could establish a SARS-CoV-2 infection mouse model without a requirement of hACE2-transgenic mice.