Structure-based phylogeny identifies Avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice

In silico docking screening of compounds for TMPRSS2 that is required for SARS-CoV-2 entry identified that Avoralstat is an efficient inhibitor for TMPRSS2 activity. The Avoralstat inhibited SARS-CoV-2 infection in human airway epithelial-derived Calu-3 cells. Moreover, the compound reduced the clinical signs of human ACE2-expressing adenovirus-transduced mice infected with SARS-CoV-2. Thus, TMPRSS2 inhibitor Avoralstat is considered to be an effective antiviral against COVID-19.