SARS-CoV-2 nonstructural protein 1 (nsp1) plays a role for host translation shut-off by blocking the mRNA entry channel of the 40S ribosomal subunit as well as promoting mRNA degradation. Various critical amino acid residues in the N-terminal domain and central region of nsp1 required for stabilizing its association with the ribosome and mRNA were identified, which were not involved in docking into the 40S mRNA entry channel.
Friday, November 5, 2021
The N-terminal domain of SARS-CoV-2 nsp1 plays key roles in suppression of cellular gene expression and preservatin of viral gene expression
Subscribe to:
Post Comments (Atom)
No comments:
Post a Comment