Ebola virus (EBOV) VP35 is a viral co-factor for RNA-dependent RNA polymerase. It was found that the VP35 interacts with a host factor human A kinase interacting protein (AKIP1) that activates protein kinase A (PKA) and PKA-downstream transcription factor CREB1, by a yeast two-hybrid assay using VP35 as a bait. CREB1 is recruited into EBOV ribonucleoprotein complexes in viral inclusion bodies, and involved in viral replication. By VP35-dependent CREB1 activation, several coagulation-related genes was found to be up-regulated, which may be directly involved in the viral hemorrhagic fever.
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