Clofazimine is a FDA-approved anti-leprosy (Mycobacterium disease) drug was effective for the inhibition SARS-CoV-2 and MERS-CoV-2 infections. This molecule was shown to inhibit both entry step and helicase activity during SARS-CoV-2 infection. Using hamster SARS-CoV-2 infection model, the therapeutic efficacy of clofazimine was confirmed, and a combination therapy with remdesivir was demonstrated to be more effective. Clofazimine is orally available drug, which is different from remdesivir.
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