The cryo-EM structures of SARS-CoV-2 spike protein of B.1.1.7 UK variant and B.1.351 South Africa variant were resolved. Amino acid substitutions in the B.1.1.7 protein increase the accessibility of its receptor binding domain that leads to the increased binding affinity to human ACE2 receptor. B.1.351 protein has been reshaped antigenic surfaces of the antibody neutralizing sites making it resistant to some potent neutralizing antibodies.
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